Abstract
2-Amino-4-aryl-3H-1,5-benzodiazepines were prepared and evaluated for potential neuroleptic activity. Compound 60 showed some activity in the four assays; however, the activity was not consistently observed among other members of the series. The data reflected that the structural modifications led to a decrease in activity relative to clozapine. It was apparent that the 1,5-benzodiazepine portion of clozapine is not responsible for its antipsychotic activity.
MeSH terms
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Adenylyl Cyclase Inhibitors
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Animals
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Antipsychotic Agents / chemical synthesis*
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Avoidance Learning / drug effects
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Brain / drug effects
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Brain / metabolism
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Clozapine / analogs & derivatives
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Clozapine / chemical synthesis*
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Clozapine / pharmacology
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Corpus Striatum / enzymology
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Dextroamphetamine / antagonists & inhibitors
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Dextroamphetamine / toxicity
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Dibenzazepines / chemical synthesis*
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Dopamine / metabolism
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Dose-Response Relationship, Drug
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In Vitro Techniques
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Male
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Mice
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Rats
Substances
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Adenylyl Cyclase Inhibitors
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Antipsychotic Agents
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Dibenzazepines
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Clozapine
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Dextroamphetamine
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Dopamine